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The year 1603 in science and technology involved some significant events.
- Johann Bayer publishes the star atlas Uranometria, the first to cover the entire celestial sphere,[1] and introducing a new system of star designation which becomes known as the Bayer designation.
- Dutch explorer Frederick de Houtman publishes his observations of the southern hemisphere constellations.[2]
- Acadia, the French colony in North America, is founded.
- Pietro Cataldi finds the sixth and seventh perfect numbers.[3]
- Girolamo Fabrici studies leg veins and notices that they have valves which only allow blood to flow toward the heart.
- August 17 – Accademia dei Lincei, the oldest scientific academy in the world, is founded in Rome by Federico Cesi.
- September 15 – John Jonston, Polish naturalist and physician (died 1675)
- Blaise Francois Pagan, French military engineer (died 1665)
- Abel Tasman, Dutch explorer (died 1659)
- February 23 – François Viète, French mathematician (born 1540)
- Robert Alaine, English astronomer (born 1558)
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