The decade of the 1460s in art involved some significant events.
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- c.1450s–1466: Piero della Francesca – The History of the True Cross (San Francesco, Arezzo)
- 1455–1460: Francesco del Cossa – Polyhymnia (Gemäldegalerie, Berlin)
- c.1455–1460: Giovanni Bellini
- c.1457–1460: Piero della Francesca – Madonna del Parto (Monterchi)
- 1459–1461: Benozzo Gozzoli – Journey of the Magi to Bethlehem frescoes in Magi Chapel, Palazzo Medici Riccardi, Florence
- c.1459–1465: Giovanni Bellini – Agony in the Garden (National Gallery, London)
- 1459–1466: Andrea Mantegna – Portrait of Carlo de' Medici
- 1460s: Nuno Gonçalves (attributed) – Saint Vincent Panels (National Museum of Ancient Art, Lisbon)
- c.1460s: Antonello da Messina – Salting Madonna
- 1460: Andrea Mantegna – St. Bernardino of Siena between Two Angels (Pinacoteca di Brera, Milan)
- c.1460: Giovanni Bellini
- c.1460: Dieric Bouts
- c.1460: Rogier van der Weyden
- c.1460–1462: Piero della Francesca – Madonna della Misericordia (Sansepolcro)
- c.1460–1463: Rogier van der Weyden – The Lamentation of Christ
- c.1460–1464: Giovanni Bellini
- Madonna with Child (Accademia Carrara, Bergamo)
- Madonna with Child (Milan)
- Madonna with Child (Museo Correr, Venice)
- Madonna with Child ("Greek Madonna", Pinacoteca di Brera, Milan)
- Madonna with Child Blessing (Gallerie dell'Accademia, Venice)
- c.1460–1464: Rogier van der Weyden – Medici Madonna
- c.1460–1470: Andrea Mantegna – Portrait of a Man (National Gallery of Art, Washington, D.C.)
- c.1461: Andrea Mantegna – Portrait of Francesco Gonzaga
- 1462
- 1462–1465: Caspar Isenmann – high altar of St Martin's Church, Colmar
- c.1462–1464: Andrea Mantegna – Death of the Virgin
- c.1462–1475: Jaume Huguet and Pau Vergós – The Consecration of Saint Augustine (Museu Nacional d'Art de Catalunya, Barcelona)
- 1463: Bernt Notke – Danse Macabre (St. Mary's Church, Lübeck)
- 1463–1465: Piero della Francesca – The Resurrection
- c.1464–1467: Dieric Bouts – The Last Supper (centre of altarpiece, St. Peter's Church, Leuven)
- c.1464–1468: Giovanni Bellini – Polyptych of S. Vincenzo Ferreri (Santi Giovanni e Paolo, Venice)
- 1465 or c.1465
- c.1465–1467: Sandro Botticelli – Virgin and Child with an Angel (Ospedale degli Innocenti, Florence)
- c.1465–1470: Giovanni Bellini – The Head of St John the Baptist (Civic Museum, Pesaro)
- c.1466: Andrea Mantegna – Portrait of Carlo de' Medici (Uffizi)
- c.1466–1469: Filippo Lippi – Madonna of Palazzo Medici-Riccardi
- 1467: Shen Zhou – Lofty Mount Lu
- c.1467: Sandro Botticelli
- c.1467–1469: Andrea del Verrocchio – Madonna of the Milk
- 1467–1470: Hans Memling
- c.1468–1469: Sandro Botticelli – Madonna and Child and Two Angels (Museo di Capodimonte, Naples)
- 1468–1470: Dieric Bouts – Altarpiece of the Last Judgment for Leuven Town Hall (survives fragmentarily)
- 1468: Bartolomé Bermejo – St Michael Triumphs Over the Devil, altarpiece for parish church of St Michael, Tous, Valencia
- 1469: Cosmè Tura – St George and the Princess (Ferrara Cathedral)
- c.1469: Sandro Botticelli – Portrait of a Young Man (Lorenzo il Popolano)
- c.1469–1470
- 1467–1471: Gérard Loyet – Burgundian goldsmith (born 1466 – died c. 1502).