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Zileuton
Chemical compound / From Wikipedia, the free encyclopedia
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Zileuton (trade name Zyflo) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used for the maintenance treatment of asthma. Zileuton was introduced in 1996 by Abbott Laboratories and is now marketed in two formulations by Cornerstone Therapeutics Inc. under the brand names Zyflo and Zyflo CR. The original immediate-release formulation, Zyflo, is taken four times per day. The extended-release formulation, Zyflo CR, is taken twice daily.
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Pronunciation | /zaɪˈluːtən/ zy-LOO-tən |
Trade names | Zyflo |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697013 |
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Routes of administration | Oral |
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Bioavailability | Not yet established |
Protein binding | 93% |
Metabolism | Hepatic (CYP1A2, CYP2C9 and CYP3A4-mediated) |
Elimination half-life | 2.5 hours |
Excretion | Renal |
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ECHA InfoCard | 100.121.111 ![]() |
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Formula | C11H12N2O2S |
Molar mass | 236.29 g·mol−1 |
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Chirality | Racemic mixture |
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Although the 600 mg immediate release tablet (Zyflo) and extended release formulation of zileuton are still available (Zyflo CR), the 300 mg immediate release tablet was withdrawn from the U.S. market on February 12, 2008.[1][2]