ZNF703
Protein-coding gene in the species Homo sapiens / From Wikipedia, the free encyclopedia
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ZNF703 is a gene which has been linked with the development of breast cancers.[5][6][7] ZNF703 is contained within the NET/N1z family responsible for regulation of transcription essential for developmental growth especially in the hindbrain.[8] Normal functions performed by ZNF703 include adhesion, movement and proliferation of cells.[8] ZNF703 directly accumulates histone deacetylases at gene promoter regions but does not bind to functional DNA.[9]
zinc finger protein 703 | |
---|---|
Identifiers | |
Symbol | ZNF703 |
NCBI gene | 80139 |
HGNC | 25883 |
RefSeq | NM_025069 |
Other data | |
Locus | Chr. 8 p12 |
Following research by scientists at Cancer Research UK, it was the first oncogene discovery in the past six years.[6]
ZNF703 is a part of 8p12 telomeric amplicon that is associated with Luminal B breast cancer. Recently, ZNF703 is identified as the driver of 8p12 locus amplification.[10]
Patients diagnosed with luminal B cancer caused by ZNF703 typically have lower recovery and survival rates than other cancer types.[11]
Drug resistance of ZNF703 has been displayed when patients are treated using anti-cancer drug Tamoxifen.[12]