ZFYVE27

Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene.^[5]

ZFYVE27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X4U
Identifiers
Aliases	ZFYVE27, PROTRUDIN, SPG33, zinc finger FYVE-type containing 27
External IDs	OMIM: 610243; MGI: 1919602; HomoloGene: 16939; GeneCards: ZFYVE27; OMA:ZFYVE27 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.2 Start 97,737,121 bp[1] End 97,760,907 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 42,152,390 bp[2] End 42,183,029 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right hemisphere of cerebellum mucosa of ileum right uterine tube anterior pituitary left ovary mucosa of transverse colon right frontal lobe right ovary tibial nerve Top expressed in granulocyte neural layer of retina substantia nigra superior frontal gyrus visual cortex primary visual cortex dentate gyrus of hippocampal formation granule cell vestibular membrane of cochlear duct trigeminal ganglion facial motor nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding protein self-association Cellular component cytoplasm integral component of membrane axon endosome recycling endosome membrane growth cone membrane dendrite plasma membrane cell projection endoplasmic reticulum membrane endoplasmic reticulum membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum tubular network nucleoplasm cytosol Biological process protein localization to plasma membrane neuron projection development neurotrophin TRK receptor signaling pathway vesicle-mediated transport positive regulation of axon extension endoplasmic reticulum tubular network formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 118813 319740 Ensembl ENSG00000155256 ENSMUSG00000018820 UniProt Q5T4F4 Q3TXX3 RefSeq (mRNA) NM_001002261 NM_001002262 NM_001174119 NM_001174120 NM_001174121 NM_001174122 NM_144588 NM_001164531 NM_177319 RefSeq (protein) NP_001002261 NP_001002262 NP_001167590 NP_001167591 NP_001167592 NP_001167593 NP_653189 NP_001158003 NP_796293 Location (UCSC) Chr 10: 97.74 – 97.76 Mb Chr 19: 42.15 – 42.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote Neurite formation. A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism (biology), is unclear. [provided by RefSeq, Mar 2010].

References

1. GRCh38: Ensembl release 89: ENSG00000155256 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018820 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger, FYVE domain containing 27".

Further reading

• Zhang C, Li D, Ma Y, Yan J, Yang B, Li P, Yu A, Lu C, Ma X (July 2012). "Role of spastin and protrudin in neurite outgrowth". Journal of Cellular Biochemistry. 113 (7): 2296–307. doi:10.1002/jcb.24100. PMID 22573551. S2CID 25893328.
• Saita S, Shirane M, Natume T, Iemura S, Nakayama KI (May 2009). "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein". The Journal of Biological Chemistry. 284 (20): 13766–77. doi:10.1074/jbc.M807938200. PMC 2679478. PMID 19289470.
• Mannan AU, Krawen P, Sauter SM, Boehm J, Chronowska A, Paulus W, Neesen J, Engel W (August 2006). "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia". American Journal of Human Genetics. 79 (2): 351–7. doi:10.1086/504927. PMC 1559503. PMID 16826525.
• Martignoni M, Riano E, Rugarli EI (July 2008). "The role of ZFYVE27/protrudin in hereditary spastic paraplegia". American Journal of Human Genetics. 83 (1): 127–8, author reply 128–30. doi:10.1016/j.ajhg.2008.05.014. PMC 2443834. PMID 18606302.
• Matsuzaki F, Shirane M, Matsumoto M, Nakayama KI (December 2011). "Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation". Molecular Biology of the Cell. 22 (23): 4602–20. doi:10.1091/mbc.E11-01-0068. PMC 3226478. PMID 21976701.
• Shirane M, Nakayama KI (November 2006). "Protrudin induces neurite formation by directional membrane trafficking". Science. 314 (5800): 818–21. Bibcode:2006Sci...314..818S. doi:10.1126/science.1134027. PMID 17082457. S2CID 1728286.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.