ZBTB7B

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene.^[5][6][7] ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]^[7]

ZBTB7B
Identifiers
Aliases	ZBTB7B, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	OMIM: 607646; MGI: 102755; HomoloGene: 7605; GeneCards: ZBTB7B; OMA:ZBTB7B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 155,002,630 bp[1] End 155,018,523 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.09 cM Start 89,284,951 bp[2] End 89,302,083 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte mucosa of transverse colon skin of abdomen skin of leg granulocyte nipple cardia body of stomach salivary gland mucosa of pharynx Top expressed in granulocyte pyloric antrum lip neural layer of retina tibiofemoral joint esophagus lens yolk sac muscle of thigh gastric mucosa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding protein homodimerization activity histone deacetylase binding Cellular component nucleus nucleoplasm Biological process multicellular organism development ectoderm development cell differentiation regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of transcription by RNA polymerase II regulation of gene expression negative regulation of T-helper 17 cell differentiation lactation positive regulation of gene expression response to insulin positive regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of insulin receptor signaling pathway positive regulation of brown fat cell differentiation adaptive thermogenesis positive regulation of SREBP signaling pathway negative regulation of transcription by RNA polymerase II NK T cell differentiation negative regulation of gene expression positive regulation of histone deacetylation negative regulation of NK T cell proliferation positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51043 22724 Ensembl ENSG00000160685 ENSMUSG00000028042 UniProt O15156 Q64321 RefSeq (mRNA) NM_001252406 NM_001256455 NM_001377451 NM_001377452 NM_001377453 NM_001377454 NM_001377455 NM_009565 NM_001355206 NM_001355211 NM_001355212 RefSeq (protein) NP_001239335 NP_001243384 NP_001364380 NP_001364381 NP_001364382 NP_001364383 NP_001364384 NP_033591 NP_001342135 NP_001342140 NP_001342141 Location (UCSC) Chr 1: 155 – 155.02 Mb Chr 3: 89.28 – 89.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Zbtb7

References

1. GRCh38: Ensembl release 89: ENSG00000160685 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028042 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Widom RL, Culic I, Lee JY, Korn JH (Dec 1997). "Cloning and characterization of hcKrox, a transcriptional regulator of extracellular matrix gene expression". Gene. 198 (1–2): 407–20. doi:10.1016/S0378-1119(97)00360-0. PMID 9370309.
6. Galera P, Musso M, Ducy P, Karsenty G (Oct 1994). "c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin". Proc Natl Acad Sci U S A. 91 (20): 9372–6. Bibcode:1994PNAS...91.9372G. doi:10.1073/pnas.91.20.9372. PMC 44814. PMID 7937772.
7. "Entrez Gene: ZBTB7B zinc finger and BTB domain containing 7B".

Further reading

• Heegaard AM, Gehron Robey P, Vogel W, et al. (1998). "Functional characterization of the human biglycan 5'-flanking DNA and binding of the transcription factor c-Krox". J. Bone Miner. Res. 12 (12): 2050–60. doi:10.1359/jbmr.1997.12.12.2050. PMID 9421237. S2CID 29523309.
• Ghayor C, Herrouin JF, Chadjichristos C, et al. (2000). "Regulation of human COL2A1 gene expression in chondrocytes. Identification of C-Krox-responsive elements and modulation by phenotype alteration". J. Biol. Chem. 275 (35): 27421–38. doi:10.1074/jbc.M002139200. PMID 10856292.
• Widom RL, Lee JY, Joseph C, et al. (2002). "The hcKrox gene family regulates multiple extracellular matrix genes". Matrix Biol. 20 (7): 451–62. doi:10.1016/S0945-053X(01)00167-6. PMID 11691585.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Kypriotou M, Beauchef G, Chadjichristos C, et al. (2007). "Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors". J. Biol. Chem. 282 (44): 32000–14. doi:10.1074/jbc.M705197200. PMID 17698844.

External links

• ZBTB7B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.