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From Wikipedia, the free encyclopedia
The Inverse electron demand Diels-Alder rection, or DAINV is an organic chemical reaction, closely related to the Diels-Alder reaction. Unlike in the Diels-Alder reaction, the DAINV is a cycloaddition between an electron-rich dienophile and an electron-poor diene.[1] During a DAINV reaction, three pi-bonds are broken, and two sigma-bonds and one new pi-bond are formed. A prototypical DAINV reaction is shown on the right.
Inverse electron demand Diels-Alder Reaction
![Thumb image](http://upload.wikimedia.org/wikipedia/commons/thumb/e/e9/DAinv_general_2.svg/320px-DAinv_general_2.svg.png)
DAINV reactions often involve heteroatoms, and can be used to form heterocyclic compounds. This makes the DAINV reaction particularly useful in natural product syntheses, where the target compounds often contain heterocycles. Recently, the DAINV reaction has been used to synthesize a drug transport system for treatment of prostate cancer cells.[2]