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Juncosamine is a conformationally constrained analogue of the N-benzylphenethylamine 25B-NBOMe and was discovered in 2011 by Jose Juncosa in the group of David E. Nichols at Purdue University[1][2]. The (S,S) isomer of Juncosamine is the most selective agonist ligand for the 5-HT2A receptor yet discovered, with a Ki of 2.5 nM at the human 5-HT2A receptor and with 124-fold selectivity for 5-HT2A over the structurally homologous 5-HT2C-receptor. Together with 25CN-NBOH,[3] Juncosamine is the only 5-HT2A agonist to exhibit this level of selectivity.
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Formula | C21H26BrNO3 |
Molar mass | 320.34 g/mol g·mol−1 |
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