User:Mr. Ibrahem/Tiagabine
From Wikipedia, the free encyclopedia
Tiagabine, sold under the brand name Gabitril, is a medication primarily used to treat epilepsy.[4] Specifically it is used for partial seizure that are not controllable by other measures.[4] Use for other disorders is discouraged.[4] It is taken by mouth, usually with food in divided doses over the day, starting at a small dose and increased gradually.[5]
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Clinical data | |
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Pronunciation | /taɪˈæɡəbiːn/ |
Trade names | Gabitril |
AHFS/Drugs.com | Monograph |
MedlinePlus | a698014 |
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Routes of administration | By mouth (tablets) |
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Pharmacokinetic data | |
Bioavailability | 90–95%[1] |
Protein binding | 96%[1] |
Metabolism | Liver (CYP450 system,[1] primarily CYP3A)[2] |
Elimination half-life | 5–8 hours[3] |
Excretion | Fecal (63%) and kidney (25%)[2] |
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Chemical and physical data | |
Formula | C20H25NO2S2 |
Molar mass | 375.55 g·mol−1 |
3D model (JSmol) | |
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Common side effects include tiredness, sleepiness, nausea, irritability, pain, and trouble sleeping.[4] In certain types of epilepsy, it may increase seizure frequency.[6] Other side effects may include suicide and Stevens-Johnson syndrome.[4] While safety in pregnancy is unclear, there are concerns it may harm the baby.[4] It is believed to work by affecting γ-aminobutyric acid (GABA).[4]
Tiagabine was approved for medical use in the United States in 1997.[4] In the United Kingdom 100 tablets of 10 mg costs the NHS about £104 as of 2021.[6] This amount in the United States costs about 300 USD.[7][8]