User:Mr. Ibrahem/Pomalidomide
From Wikipedia, the free encyclopedia
Pomalidomide, sold under the brand name Pomalyst and Imnovid, is a medication used to treat multiple myeloma (MM) and Kaposi sarcoma (KS).[4] For MM it is used when other treatments have failed.[4] For KS it is used when HAART is not affected or in those who are HIV negative.[4] It is taken by mouth.[4]
Clinical data | |
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Trade names | Pomalyst, Imnovid |
AHFS/Drugs.com | Monograph |
MedlinePlus | a613030 |
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Pregnancy category |
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Routes of administration | By mouth (capsules) |
Drug class | Thalidomide analog[2] |
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Pharmacokinetic data | |
Bioavailability | 73% (at least)[6] |
Protein binding | 12–44% |
Metabolism | Liver (mostly CYP1A2- and CYP3A4-mediated; some minor contributions by CYP2C19 and CYP2D6) |
Elimination half-life | 7.5 hours |
Excretion | Urine (73%), faeces (15%) |
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Chemical and physical data | |
Formula | C13H11N3O4 |
Molar mass | 273.248 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
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NY (what is this?) (verify) |
Common side effects include tiredness, low neutrophils, low red blood cells, nausea, diarrhea, shortness of breath, fever, and low platelets.[4] Other side effects may include liver problems, tumor lysis syndrome, blood clots, and anaphylaxis.[4] Use in pregnancy may harm the baby.[4] It is similar to thalidomide and works by altering the immune system.[2][5]
Pomalidomide was approved for medical use in the United States and Europe in 2013.[4][5] In the United Kingdom 4 weeks of treatment costs the NHS about £8,900 as of 2021.[7] In the United States this amount costs about 20,000 USD.[8]