User:Mr. Ibrahem/Nitrofurantoin
From Wikipedia, the free encyclopedia
Nitrofurantoin, sold under the brand name Macrobid among others, is an antibiotic used to prevent and treat bladder infections, but is not as effective for kidney infections.[1][2] It is taken by mouth.[1]
Clinical data | |
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Trade names | Macrobid, Macrodantin and others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682291 |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 40% |
Metabolism | Liver (75%) |
Elimination half-life | 20 minutes |
Excretion | Urine and bile |
Identifiers | |
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Chemical and physical data | |
Formula | C8H6N4O5 |
Molar mass | 238.16 g·mol−1 |
3D model (JSmol) | |
Melting point | 270 to 272 °C (518 to 522 °F) (decomp.) |
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NY (what is this?) (verify) |
Common side effects include nausea, loss of appetite, diarrhea, and headaches.[1] Rarely numbness, lung problems, or liver problems may occur.[1] It should not be used in people with kidney problems.[1] While it appears to be generally safe during pregnancy it should not be used near delivery.[1][3] While it usually works by slowing bacterial growth, it may result in bacterial death at the high concentrations found in urine.[1]
Nitrofurantoin was first sold in 1953.[4] It is on the World Health Organization's List of Essential Medicines.[5] It is available as a generic medication.[1] The wholesale cost in the developing world is between US$0.10 and US$9.20 for a course of treatment.[6] In the United States, the wholesale cost is about US$8 for a course of treatment as of 2018.[7] In Canada this is about 21 CAD as of 2023.[8] In 2017, it was the 185th most commonly prescribed medication in the United States, with more than three million prescriptions.[9][10]