User:Mr. Ibrahem/Meropenem
From Wikipedia, the free encyclopedia
Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.[1] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.[1] It is given by injection into a vein.[1]
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Clinical data | |
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Trade names | Merrem, others |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous |
Drug class | Antibiotic (carbapenem)[1] |
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Pharmacokinetic data | |
Bioavailability | 100% |
Protein binding | Approximately 2% |
Elimination half-life | 1 hour |
Excretion | Kidney |
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Chemical and physical data | |
Formula | C17H25N3O5S |
Molar mass | 383.46 g·mol−1 |
3D model (JSmol) | |
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Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection.[1] Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis.[1] Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well.[1] Use in pregnancy appears to be safe.[1] It is in the carbapenem family of medications.[1] Meropenem usually results in bacterial death through blocking their ability to make a cell wall.[1] It is more resistant to breakdown by β-lactamase producing bacteria.[1]
Meropenem was patented in 1983.[2] It was approved for medical use in the United States in 1996.[1] It is on the World Health Organization's List of Essential Medicines.[3] The wholesale cost in the developing world is between 3.44 and 20.58 USD per one gram vial as of 2015.[4] In the United Kingdom this amount costs the NHS about £16 in 2015.[5]