User:Mr. Ibrahem/Foscarnet
From Wikipedia, the free encyclopedia
Foscarnet, sold under the brand name Foscavir, is an antiviral used to treat cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV).[2] Primarily this is those who are immunocompromised such as due to HIV/AIDS.[2] It is given by injection into a vein.[3]
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Clinical data | |
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Trade names | Foscavir |
Other names | Foscarnet sodium, phosphonomethanoic acid, dihydroxyphosphinecarboxylic acid oxide |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601144 |
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Routes of administration | Intravenous |
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Pharmacokinetic data | |
Bioavailability | NA |
Protein binding | 14–17% |
Elimination half-life | 3.3–6.8 hours |
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Chemical and physical data | |
Formula | CH3O5P |
Molar mass | 126.004 g·mol−1 |
3D model (JSmol) | |
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Common side effects include fever, nausea, low red blood cells, kidney problems, seizures, and headache.[2] Other side effects may include electrolyte abnormalities, prolonged QT, and anaphylaxis.[2] Safety in pregnancy is unclear.[2] It acts similar to pyrophosphate as a viral DNA polymerase inhibitor.[2]
Foscarnet was approved for medical use in the United States in 1991.[4][2] In the United Kingdom 6 grams costs the NHS about £120 as of 2021.[3] This amount in the United States cost about 4,800 USD.[5]