User:Mr. Ibrahem/Fexofenadine
From Wikipedia, the free encyclopedia
Fexofenadine, sold under the brand name Allegra among others, is an antihistamine medication used to treat allergy symptoms, such as hay fever and urticaria.[7][8] It is taken by mouth.[6] Effects generally occur within 3 hours and last for about 12 hours.[6]
![]() | |
![]() | |
Clinical data | |
---|---|
Trade names | Allegra, FX 24, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a697035 |
License data |
|
Pregnancy category |
|
Routes of administration | By mouth |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 30-41%[4] |
Protein binding | 60-70%[5] |
Metabolism | Liver (≤5% of dose)[5] |
Onset of action | < 3 hrs[6] |
Elimination half-life | 14.4 hours |
Duration of action | 12 hrs[6] |
Excretion | Feces (~80%) and urine (~10%) as unchanged drug[5] |
Identifiers | |
| |
Chemical and physical data | |
Formula | C32H39NO4 |
Molar mass | 501.667 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
| |
| |
![]() ![]() |
Common side effects include sleepiness, headache, nausea, and dizziness.[7] Sleepiness is less than with first-generation antihistamines.[6] Other side effects may include allergic reactions.[6] It is classified as a second-generation antihistamine and works as a selective H1-blocker.[6]
Fexofenadine was patented in 1979 and came into medical use in 1996.[9] It is on the World Health Organization's List of Essential Medicines as an alternative to loratadine.[10] It has been avaliable as a generic medication since 2011.[11] In the United Kingdom 30 tablets costs the NHS about 2 pounds while this amount costs in the United States about 9 USD as of 2020.[7][12] In 2017, it was the 245th most commonly prescribed medication in the United States, with more than one million prescriptions.[13][14]