User:Mr. Ibrahem/Escitalopram
From Wikipedia, the free encyclopedia
Escitalopram, sold under the brand names Cipralex and Lexapro, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.[2] Escitalopram is mainly used to treat major depressive disorder or generalized anxiety disorder.[2] It is taken by mouth.[2]
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Pronunciation | /ˌɛsəˈtæləˌpræm/ pronunciationⓘ |
Trade names | Cipralex, Lexapro, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603005 |
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Routes of administration | By mouth |
Drug class | Selective serotonin reuptake inhibitor |
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Bioavailability | 80% |
Protein binding | ~56% |
Metabolism | Liver, specifically the enzymes CYP3A4 and CYP2C19 |
Elimination half-life | 27–32 hours |
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Formula | C20H21FN2O |
Molar mass | 324.392 g/mol (414.43 as oxalate) g·mol−1 |
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Common side effects include trouble sleeping, nausea, sexual problems, and feeling tired.[2] More serious side effects may include suicide in people under the age of 25.[2] It is unclear if use during pregnancy or breastfeeding is safe.[3] Escitalopram is the (S)-stereoisomer (left-handed version) of citalopram (which is a mixture of both right and left handed), hence the name escitalopram.[2]
Escitalopram was approved for medical use in the United States in 2002.[2] It is on the World Health Organization's List of Essential Medicines as an alternative to fluoxetine.[4] In the United States the wholesale cost is about $2.04 per month as of 2017[update].[5] In the United Kingdom, as of 2018[update], generic escitalopram is around 1/20th as costly as the proprietary version.[6] Escitalopram is sometimes replaced by twice the dose of citalopram.[7] In 2017, it was the 20th most commonly prescribed medication in the United States with more than 25 million prescriptions.[8][9]