User:Mr. Ibrahem/Erlotinib
From Wikipedia, the free encyclopedia
Erlotinib, sold under the brand name Tarceva among others, is a medication used to treat non-small cell lung cancer (NSCLC) and pancreatic cancer.[2] Specifically it is used for NSCLC with mutations in the epidermal growth factor receptor (EGFR) — either an exon 19 deletion (del19) or exon 21 (L858R) substitution mutation — which has spread to other parts of the body.[2] It is taken by mouth.[2]
Clinical data | |
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Trade names | Tarceva |
Other names | Erlotinib hydrochloride |
AHFS/Drugs.com | Monograph |
MedlinePlus | a605008 |
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Routes of administration | By mouth tablets |
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Pharmacokinetic data | |
Bioavailability | 59% |
Protein binding | 95% |
Metabolism | Liver (mainly CYP3A4, less CYP1A2) |
Elimination half-life | 36.2 hrs (median) |
Excretion | >98% as metabolites, of which >90% via feces, 9% via urine |
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Chemical and physical data | |
Formula | C22H23N3O4 |
Molar mass | 393.443 g·mol−1 |
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Common side effects include rash, diarrhea, muscle pain, joint pain, and cough.[2][3] Serious side effects may include lung problems, kidney problems, liver failure, gastrointestinal perforation, stroke, and corneal ulceration.[2] Use in pregnancy may harm the baby.[2] It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).[2]
Erlotinib was approved for medical use in the United States in 2004.[4][2][3] It is on the World Health Organization's List of Essential Medicines.[5] In the United States, as of 2019[update], it costs about US$8,832 per month.[6] In the United Kingdom this amount costs the NHS about £1,632 per month.[7]