User:Mr. Ibrahem/Ergometrine
From Wikipedia, the free encyclopedia
Ergometrine, also known as ergonovine, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth.[1] It can be used either by mouth, by injection into a muscle, or injection into a vein.[1] It begins working within 15 minutes when taken by mouth and is faster in onset when used by injection.[1] Effects last between 45 and 180 minutes.[1]
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Other names | Ergonovine, d-lysergic acid beta-propanolamide | ||
AHFS/Drugs.com | Monograph | ||
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Routes of administration | By mouth | ||
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Metabolism | Liver (partly CYP3A4) | ||
Elimination half-life | 2-phase (10 min; 2 hrs) | ||
Excretion | Biliary | ||
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Formula | C19H23N3O2 | ||
Molar mass | 325.412 g·mol−1 | ||
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Common side effect include high blood pressure, vomiting, seizures, headache, and low blood pressure.[1] Other serious side effects include ergotism.[1] It was originally made from the rye ergot fungus but can also be made from lysergic acid.[2][3] Ergometrine is regulated because it can be used to make lysergic acid diethylamide (LSD).[4]
Ergometrine was discovered in 1932.[2] It is on the World Health Organization's List of Essential Medicines.[5] The wholesale cost in the developing world is between US$0.12 and US$0.41 for an injectable dose and US$0.01 for a pill as of 2014.[6][7] In the United States it is about US$1.75 per dose.[1]