User:Mr. Ibrahem/Eplerenone
From Wikipedia, the free encyclopedia
Eplerenone, sold under the brand name Inspra among others, is a medication used to treat heart failure and high blood pressure.[4] For high blood pressure it is a second line treatment.[4] It is taken by mouth.[4] Effects generally occur within 2 weeks.[4]
Clinical data | |
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Pronunciation | /ɛpˈlɛrənoʊn/ |
Trade names | Inspra, Epnone, Dosterep, others |
Other names | SC-66110; CGP-30083; 9-11α-Epoxymexrenone; 9,11α-Epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone |
AHFS/Drugs.com | Monograph |
MedlinePlus | a603004 |
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Routes of administration | By mouth (tablets) |
Drug class | Aldosterone antagonist, potassium-sparing diuretic[1] |
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Pharmacokinetic data | |
Bioavailability | ~70%[2] |
Protein binding | ~50% (33–60%) (primarily to α1-acid glycoprotein)[2][3] |
Metabolism | Liver (CYP3A4)[2][3] |
Metabolites | 6β-OH-EPL, 6β,21-OH-EPL, 21-OH-EPL, 3α,6β-OH-EPL[2] (All inactive)[2] |
Onset of action | Within 2 weeks[4] |
Elimination half-life | 4–6 hours[5] |
Excretion | Urine (67%), feces (32%)[6] |
Identifiers | |
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Chemical and physical data | |
Formula | C24H30O6 |
Molar mass | 414.498 g·mol−1 |
3D model (JSmol) | |
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Common side effects include high blood potassium, diarrhea, breast enlargement, and abdominal pain.[4] Other side effects may include arrhythmias, angioedema, and low blood pressure with standing.[1] It is a aldosterone antagonist and a potassium-sparing diuretic.[1]
Eplerenone was approved for medical use in the United States in 2002.[4] It is available as a generic medication.[1] In the United Kingdom a month of medication costs the NHS about £25.[1] This amount in the United States costs about 19 USD as of 2021.[7]