User:Mr. Ibrahem/Desipramine
From Wikipedia, the free encyclopedia
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used to treat depression, panic disorder, and postherpetic neuralgia.[7] While benefits may be seen within 5 days, up to 3 weeks may be required for full effects.[7]
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Clinical data | |
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Trade names | Norpramin, Pertofrane, others |
Other names | Desmethylimipramine; Norimipramine; EX-4355; G-35020; JB-8181; NSC-114901[1][2][3] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682387 |
Routes of administration | By mouth, intramuscular injection |
Drug class | Tricyclic antidepressant[4] |
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Pharmacokinetic data | |
Bioavailability | 60–70%[5] |
Protein binding | 91%[5] |
Metabolism | Liver (CYP2D6)[6] |
Elimination half-life | 12–30 hours[5] |
Excretion | Urine (70%), feces[5] |
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Chemical and physical data | |
Formula | C18H22N2 |
Molar mass | 266.388 g·mol−1 |
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Common side effects include dry mouth, constipation, blurry vision, low blood pressure with standing, sleepiness, and weakness.[7] Other side effects may include suicide, mania, arrythmias, and seizures.[7] Safety in pregnancy is unclear.[7] How it works is unclear, but is believed to involve effects on serotonin and norepinephrine.[7]
Desipramine was approved for medical use in the United States in 1964.[7] It is available as a generic medication.[4] In the United States 30 tablets of 100 mg costs about 25 USD as of 2021.[8] It has been widely used.[4]