User:Mr. Ibrahem/Clofarabine
From Wikipedia, the free encyclopedia
Clofarabine, sold under the brand name Clolar and Evoltra, is a medication used to treat acute lymphoblastic leukaemia (ALL).[3] It is used when other treatments stop working.[3] It is given by gradual injection into a vein.[3]
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Trade names | Clolar, Evoltra, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607012 |
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Routes of administration | Intravenous |
Drug class | Antimetabolite[1] |
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Chemical and physical data | |
Formula | C10H11ClFN5O3 |
Molar mass | 303.68 g·mol−1 |
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Common side effects include low white blood cells with a fever, anxiety, headache, flushing, nausea, diarrhea, itchiness, and tiredness.[1] Other side effects may include bone marrow suppression and tumor lysis syndrome.[3] Use during pregnancy may harm the baby.[3] It is a antimetabolite, specifically an analogue of adenine.[1] As such it disrupts DNA polymerase and RNA reductase preventing the making of new DNA and RNA.[1]
Clofarabine was approved for medical use in the United States in 2004 and Europe in 2006.[3][1] It is available as a generic medication.[4] In the United Kingdom 20 mg costs the NHS about £1,325 as of 2021.[4] In the United States this amount costs about 650 USD.[5]