User:Mr. Ibrahem/Calcium channel blocker
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Calcium channel blockers (CCB) are a class of medication made up of two main groups dihydropyridines and non-dihydropyridines.[2] Common dihydropyridines include amlodipine and nifedipine and non-dihydropyridines include diltiazem and verapamil.[3] Both types are used for stable angina, while dihydropyridines are used for high blood pressure, and non-dihydropyridines are used for atrial fibrillation.[3] Other uses include cluster headache, pulmonary hypertension, and subarachnoid hemorrhage.[4][5] They can be take by mouth or given by injection into a vein.[2]
Mr. Ibrahem/Calcium channel blocker | |
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Drug class | |
Synonyms | Calcium channel antagonists, calcium antagonists, calcium entry blockers[1] |
Clinical data | |
Drugs.com | Drug Classes |
Legal status |
Common side effects of dihydropyridines include headaches and swelling while non-dihydropyridines can result in a slow heart rate, constipation, and heart failure.[3] They work by blocking movement of calcium (Ca2+
) into cell.[3] Dihydropyridines mainly affect blood vessels resulting in vasodilation while non-dihydropyridines mainly affect the heart resulting in decreased contraction.[2] Overdose is associated with a high risk of death.[5]
Calcium channel blockers were discovered in 1964, with the first useful agent being verapamil.[6][7] They are commonly used.[5] A number of agents are available as generic medication and not very expensive.[3]