User:Mr. Ibrahem/Acamprosate
From Wikipedia, the free encyclopedia
Acamprosate, sold under the brand name Campral among others, is a medication used along with counselling to treat alcohol dependence.[1] When used alone, it is not effective for most individuals;[3] it works best when used in combination with counselling.[1][4] It is taken by mouth.[5]
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Clinical data | |
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Pronunciation | /əˈkæmproʊseɪt/ |
Trade names | Campral, Aotal, others[1] |
Other names | N-Acetyl homotaurine, Acamprosate calcium (JAN JP), Acamprosate calcium (USAN US) |
AHFS/Drugs.com | Monograph |
Pregnancy category | |
Routes of administration | By mouth[2] |
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Pharmacokinetic data | |
Bioavailability | 11%[2] |
Protein binding | Negligible[2] |
Metabolism | Nil[2] |
Elimination half-life | 20 h to 33 h[2] |
Excretion | Kidney[2] |
Identifiers | |
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Chemical and physical data | |
Formula | C5H11NO4S |
Molar mass | 181.21 g·mol−1 |
3D model (JSmol) | |
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Common side effects include diarrhea and weakness.[6] Serious side effects may include allergic reactions, mood changes, thoughts of suicide, and heart palpitations.[7] A lower dose is recommended in people with mild kidney problems and use is not recommended in people with severe kidney disease.[6] Use is okay in mild to moderate liver dysfunction.[8] Safety during pregnancy is unclear.[9] Acamprosate is thought to work by altering chemical signaling in the brain.[8]
Acamprosate was approved for medical use in the United States in 2004.[6] It is on the World Health Organization's List of Essential Medicines.[10] It is available as a generic medication in the United Kingdom were a month of treatment costs the NHS about 30 pounds as of 2020.[5] This amount in the United States costs as little as 80 USD as of 2020.[11]