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From Wikipedia, the free encyclopedia
Cefazolin (INN), also known as cefazoline or cephazolin, is an antibiotic used for the treatment of a number of bacterial infections.[1] It is marketed by GlaxoSmithKline under the trade name Ancef, but is no longer available as brand name products.[2]
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Trade names | Ancef, Cefacidal, Cefamezin, Cefrina, Elzogram, Faxilen, Gramaxin, Kefzol, Kefol, Kefzolan, Kezolin, Novaporin, Reflin, Zinol Zolicef |
AHFS/Drugs.com | Monograph |
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Routes of administration | Intravenous, intramuscular |
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Bioavailability | NA |
Metabolism | ? |
Elimination half-life | 1.8 hours (given IV) 2 hours (given IM) |
Excretion | Renal, unchanged |
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Formula | C14H14N8O4S3 |
Molar mass | 454.51 g/mol g·mol−1 |
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Cefazolin is a first-generation cephalosporin antibiotic with broad spectrum antibiotic with activity against both gram-negative and gram-positive bacteria. Due to cross-reactivity with penicillins, patients who have experienced anaphylaxis to penicillins are not advised to receive cephalosporins.[1] Common side effects include nausea, vomiting, diarrhea, and rash.[3] The drug is usually administered by either intramuscular injection (injection into a large muscle) or intravenous infusion (intravenous fluid into a vein).[2] It is on the World Health Organization's List of Essential Medicines for use in a basic health system.[4]