User:Kkyann27/sandbox
From Wikipedia, the free encyclopedia
[1] Trimethoprim (TMP) is an antibiotic used [2]mainly in the treatment of urinary tract infections.[3] Other uses include for middle ear infections and travelers' diarrhea. With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. It is taken by mouth.[3]
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Pronunciation | /traɪˈmɛθəprɪm/ |
Trade names | Proloprim, Monotrim, Triprim, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a684025 |
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Routes of administration | Oral |
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Bioavailability | 90–100% |
Protein binding | 44% |
Metabolism | hepatic |
Elimination half-life | 8-12 hours |
Excretion | Urine (50–60%), faeces (4%) |
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Formula | C14H18N4O3 |
Molar mass | 290.32 g/mol g·mol−1 |
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Common side effects include nausea, changes in taste, and rash. Rarely it may result in blood problems such as not enough platelets or white blood cells. May cause sun sensitivity.[3] There is evidence of potential harm during pregnancy in some animals but not humans.[4] It works by blocking folate metabolism in some bacteria which results in their death.[3]
Trimethoprim was first used in 1962.[5] It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.[6] It is available as a generic medication and is not very expensive.[7] In the United States 10 days of treatment is about 21 USD.[3]