User:Joilybbi/5-HT3 antagonists drug discovery and development
From Wikipedia, the free encyclopedia
5-HT3 receptor antagonists or serotonin receptor antagonists were first introduced in the early 1990s, and they have become the most widely used antiemetic drugs in chemotherapy.[1] They have also been proven safe and effective for treatment of postoperative nausea and vomiting.[2] Serotonin (5-HT) is found widely distributed throughout the gut and the central nervous system. In the gut, 5-HT is found mostly in mucosal enterochromaffin cells. Enterochromaffin cells are sensory transducers that release 5-HT to activate intrinsic (via 5-HT1P and 5-HT4 receptors) and extrinsic (via 5-HT3 receptors) primary afferent nerves.[3] Chemotherapeutic drugs for malignant disorders that cause vomiting have been found to cause release of large amounts of serotonin from enterochromaffin cells in the gut, serotonin acts on 5-HT3 receptors in the gut and brain stem. [3]