User:JeanOhm/Nucleolus
From Wikipedia, the free encyclopedia
This is a revision in progress of the Nucleolus page
This is the user sandbox of JeanOhm. A user sandbox is a subpage of the user's user page. It serves as a testing spot and page development space for the user and is not an encyclopedia article. Create or edit your own sandbox here. Other sandboxes: Main sandbox | Template sandbox Finished writing a draft article? Are you ready to request review of it by an experienced editor for possible inclusion in Wikipedia? Submit your draft for review! |
The nucleolus (/njuːˈkliːələs/ or /ˌnjuːkliˈoʊləs/, plural nucleoli /njuːˈkliːəlaɪ/ or /ˌnjuːkliˈoʊlaɪ/ is the largest structure in the nucleus of eukaryotic cells.[1] Nucleoli are made of proteins, DNA and RNA and form around specific chromosomal regions called nucleolar organizing regions. As early as 2010, the authors of a review wrote:
"The nucleolus has been recognized as a dynamic organelle with many more functions than one could imagine."[2]
It is best known as the site of ribosome biogenesis. Nucleoli also participate in the formation of signal recognition particles and play a role in the cell's response to stress.[3] Nucleoli are also involved in cell cycle control,[4] organization of the genome[1] and many other functions. Malfunction of nucleoli can be the cause of several human conditions called "nucleolopathies"[5] and the nucleolus is being investigated as a target for cancer chemotherapy.[6][7]