User:Iridiumhusky/sandbox
From Wikipedia, the free encyclopedia
Krüppel is a gap gene in Drosophila melanogaster, located on the 2R chromosome, which encodes a zinc finger C2H2 transcription factor.[1][2] Gap genes work together to establish the anterior-posterior segment patterning of the insect through regulation of the transcription factor encoding pair rule genes. These genes in turn regulate segment polarity genes.[3] Krüppel means "cripple" in German, named for the crippled appearance of mutant larvae, who have failed to develop proper thoracic and anterior segments in the abdominal region.[4][5][6] Mutants can also have abdominal mirror duplications.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/c/c3/Drosophila_gap_gene_in_situ_brakeless_mutant.png/640px-Drosophila_gap_gene_in_situ_brakeless_mutant.png)
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Human homologs of Krüppel are collectively named Krüppel-like factors, a set of proteins well characterized for their role in carcinogenesis.[7][8][9][10][11]