User:Hsrinimukesh3/Hereditary diffuse leukoencephalopathy with spheroids (HDLS)
Medical condition / From Wikipedia, the free encyclopedia
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare adult onset autosomal dominant disorder characterized by cerebral white matter degeneration with axonal spheroids leading to progressive cognitive and motor dysfunction. It is believed that the disease arises from primary disruption of axonal integrity, neuroaxonal damage, and focal axonal spheroids leading to demyelination. Specifically, shear stress damages the axons, causing them to swell to spherical clumps. The blockage of axoplasmic transport resulting from these axonal spheroids can cause trauma, stroke, and many other symptoms seen in degenerative diseases.[1] It is uncertain whether demyelination occurs prior to the axonal spheroids to trigger autonomous neurodegeneration.[2] It is commonly mistaken for Alzheimer's disease, Frontotemporal dementia, Atypical Parkinsonism, Multiple sclerosis, and Corticobasal degeneration.[3]
This user page or section is in a state of significant expansion or restructuring. You are welcome to assist in its construction by editing it as well. If this user page has not been edited in several days, please remove this template. If you are the editor who added this template and you are actively editing, please be sure to replace this template with {{in use}} during the active editing session. Click on the link for template parameters to use.
This page was last edited by Jonesey95 (talk | contribs) 9 months ago. (Update timer) |
This article is an orphan, as no other articles link to it. Please introduce links to this page from related articles; try the Find link tool for suggestions. (December 2011) |
Hsrinimukesh3/Hereditary diffuse leukoencephalopathy with spheroids (HDLS) |
---|