User:Dmil3422/Laron Syndrome
Medical condition / From Wikipedia, the free encyclopedia
Laron syndrome, or Laron-type dwarfism, is an autosomal recessive disorder characterized by an insensitivity to growth hormone (GH), usually caused by a mutant growth hormone receptor. It causes a short stature and an increased sensitivity to insulin which means that diabetes mellitus type 2 is less likely to develop,[1] and possibly cancer as well. It can be treated with injections of recombinant IGF-1.
Quick Facts Laron syndrome, Other names ...
Laron syndrome | |
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Other names | Laron-type dwarfism, Growth Hormone Insufficiency |
Growth hormone | |
Specialty | Endocrinology |
Symptoms | Short stature, truncal obesity |
Usual onset | Present at birth |
Duration | Lifelong |
Causes | Autosomal recessive growth hormone receptor gene mutation |
Risk factors | Seizures, reduced intellectual capacity |
Differential diagnosis | STAT5b, IGF1 gene mutation, ALS deficiency, IGF-1 receptor mutation, congenital short stature |
Treatment | IGF-1 |
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