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Argininosuccinate synthase or synthetase (ASS) (EC 6.3.4.5) is an enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate.
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Quick Facts Argininosuccinate synthetase, Identifiers ...
Argininosuccinate synthetase | |||||||||
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![]() Crystallographic structure of human argininosuccinate synthetase.[1] | |||||||||
Identifiers | |||||||||
EC no. | 6.3.4.5 | ||||||||
CAS no. | 9023-58-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Quick Facts Argininosuccinate synthetase 1, Identifiers ...
Argininosuccinate synthetase 1 | |||||||
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Identifiers | |||||||
Symbol | ASS1 | ||||||
NCBI gene | 445 | ||||||
HGNC | 758 | ||||||
OMIM | 603470 | ||||||
RefSeq | NM_000050 | ||||||
UniProt | P00966 | ||||||
Other data | |||||||
EC number | 6.3.4.5 | ||||||
Locus | Chr. 9 q34.1 | ||||||
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![](http://upload.wikimedia.org/wikipedia/commons/thumb/0/04/Citrulline_metabolism.png/640px-Citrulline_metabolism.png)
Quick Facts Argininosuccinate synthetase, Identifiers ...
Argininosuccinate synthetase | |||||||||
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![]() crystal structure of thermus thermophilus hb8 argininosuccinate synthetase in complex with atp and citrulline | |||||||||
Identifiers | |||||||||
Symbol | Arginosuc_synth | ||||||||
Pfam | PF00764 | ||||||||
Pfam clan | CL0039 | ||||||||
InterPro | IPR001518 | ||||||||
PROSITE | PDOC00488 | ||||||||
SCOP2 | 1kp2 / SCOPe / SUPFAM | ||||||||
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ASS is responsible for the third step of the urea cycle and one of the reactions of the citrulline-NO cycle.