User:3shalim26/sandbox
From Wikipedia, the free encyclopedia
Hydrocodone/paracetamol, hydrocodone/acetaminophen, or hydrocodone/APAP (marketed under trade names such as Lortab, Norco and Vicodin) is a combination opioid narcotic and analgesic drug consisting of hydrocodone and paracetamol (acetaminophen) used to relieve moderate to severe pain.[1] It exists in tablet, elixir and solution in various strengths for oral administration.[2] In 2007, 99% of hydrocodone was consumed in the United States.[3] It was the most commonly prescribed opioid in the United States as of 2012. About 142 million prescriptions were dispensed in the US for hydrocodone-combination products, and the hydrocodone/acetaminophen combination was the most common of those.[4]
Quick Facts Combination of, Hydrocodone ...
Combination of | |
---|---|
Hydrocodone | Opioid analgesic |
Paracetamol | Anilide analgesic |
Clinical data | |
Trade names | Hycet, Lorcet, Lorcet Plus, Lortab, Maxidone, Norco, Vicodin, Vicodin ES, Vicodin HP, Zamicet, and Zydone (possibly others) |
AHFS/Drugs.com | hydrocodone/paracetamol |
Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | >80% |
Metabolism | for hydrocodone: extensively hepatic, primarily CYP3A4; for acetaminophen: hepatic, CYP2E1 |
Elimination half-life | for hydrocodone: 228-294 mins (3.8-4.9 hrs); for acetaminophen: 120-240 mins (2-4 hrs) |
Excretion | for hydrocodone: urinary; for acetaminophen: urinary (10-15% unchanged) |
Identifiers | |
PubChem CID | |
ChemSpider |
|
Chemical and physical data | |
3D model (JSmol) | |
| |
| |
(verify) |
Close