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Chemical compound From Wikipedia, the free encyclopedia
URB602 ([1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester) is a compound that has been found to inhibit hydrolysis of monoacyl glycerol compounds, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol (2-OG). It was first described in 2003.[1] A study performed in 2005 found that the compound had specificity for metabolizing 2-AG over anandamide (another cannabinoid ligand) in rat brain presumably by inhibiting the enzyme monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG.[2] However, subsequent studies have shown that URB602 lacks specificity for MAGL inhibition in vitro.[3]
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Preferred IUPAC name
Cyclohexyl ([1,1′-biphenyl]-3-yl)carbamate | |
Other names
[1,1′-Biphenyl]-3-yl-carbamic acid, cyclohexyl ester | |
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Properties | |
C19H21NO2 | |
Molar mass | 295.382 g·mol−1 |
Appearance | Crystalline solid |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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