UGT2B17

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.^[5][6]

UGT2B17
Identifiers
Aliases	UGT2B17, BMND12, UDPGT2B17, UDP glucuronosyltransferase family 2 member B17
External IDs	OMIM: 601903; MGI: 1919023; HomoloGene: 68144; GeneCards: UGT2B17; OMA:UGT2B17 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 68,537,173 bp[1] End 68,576,413 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 87,064,497 bp[2] End 87,074,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon mucosa of ileum mucosa of sigmoid colon duodenum appendix epithelium of colon jejunal mucosa rectum right lobe of liver pancreatic epithelial cell Top expressed in left lobe of liver embryo lumbar subsegment of spinal cord right ventricle tibiofemoral joint sexually immature organism medial head of gastrocnemius muscle lumbar spinal ganglion stria vascularis carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity glucuronosyltransferase activity retinoic acid binding hexosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane organelle membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process steroid metabolic process metabolism cellular glucuronidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7367 71773 Ensembl ENSG00000197888 ENSMUSG00000035836 UniProt O75795 Q8R084 RefSeq (mRNA) NM_001077 NM_152811 RefSeq (protein) NP_001068 NP_690024 Location (UCSC) Chr 4: 68.54 – 68.58 Mb Chr 5: 87.06 – 87.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM]^[6] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000197888 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035836 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi:10.1074/jbc.271.37.22855. PMID 8798464.
6. "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".
7. Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

Further reading

• Chung LW, Coffey DS (1978). "Androgen glucuronide. II. Differences in its formation by human normal and benign hyperplastic prostates". Investigative Urology. 15 (5): 385–8. PMID 76619.
• Moghissi E, Ablan F, Horton R (1984). "Origin of plasma androstanediol glucuronide in men". J. Clin. Endocrinol. Metab. 59 (3): 417–21. doi:10.1210/jcem-59-3-417. PMID 6746859.
• Beaulieu M, Lévesque E, Tchernof A, et al. (1997). "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme". DNA Cell Biol. 16 (10): 1143–54. doi:10.1089/dna.1997.16.1143. PMID 9364925.
• Collier AC, Ganley NA, Tingle MD, et al. (2002). "UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term". Biochem. Pharmacol. 63 (3): 409–19. doi:10.1016/S0006-2952(01)00890-5. PMID 11853692.
• Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. S2CID 10971899.
• Lazarus P, Zheng Y, Aaron Runkle E, et al. (2006). "Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes". Pharmacogenet. Genomics. 15 (11): 769–78. doi:10.1097/01.fpc.0000175596.52443.ef. PMID 16220109. S2CID 10171438.
• Jakobsson J, Ekström L, Inotsume N, et al. (2006). "Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism". J. Clin. Endocrinol. Metab. 91 (2): 687–93. doi:10.1210/jc.2005-1643. PMID 16332934.
• Park J, Chen L, Ratnashinge L, et al. (2006). "Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men". Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473–8. doi:10.1158/1055-9965.EPI-06-0141. PMID 16896035.
• Gallagher CJ, Muscat JE, Hicks AN, et al. (2007). "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer". Cancer Epidemiol. Biomarkers Prev. 16 (4): 823–8. doi:10.1158/1055-9965.EPI-06-0823. PMID 17416778.
• Park JY, Tanner JP, Sellers TA, et al. (2007). "Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk". Urology. 70 (2): 374–9. doi:10.1016/j.urology.2007.03.001. PMID 17826523.
• Chouinard S, Barbier O, Bélanger A (2008). "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells". J. Biol. Chem. 282 (46): 33466–74. doi:10.1074/jbc.M703370200. PMID 17848572.