Trans-regulatory element
From Wikipedia, the free encyclopedia
Trans-regulatory elements (TRE) are DNA sequences encoding upstream regulators (ie. trans-acting factors), which may modify or regulate the expression of distant genes.[1] Trans-acting factors interact with cis-regulatory elements to regulate gene expression.[2] TRE mediates expression profiles of a large number of genes via trans-acting factors.[3] While TRE mutations affect gene expression, it is also one of the main driving factors for evolutionary divergence in gene expression.[3]