![cover image](https://wikiwandv2-19431.kxcdn.com/_next/image?url=https://upload.wikimedia.org/wikipedia/commons/thumb/8/84/Trametinib.svg/640px-Trametinib.svg.png&w=640&q=50)
Trametinib
Anticancer medication / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Trametinib?
Summarize this article for a 10 year old
Trametinib, sold under the brand name Mekinist among others, is an anticancer medication used for the treatment of melanoma[4][5] and glioma.[6][7] It is a MEK inhibitor drug with anti-cancer activity.[8] It inhibits MEK1 and MEK2.[8] It is taken by mouth.[4][5]
![]() | |
Clinical data | |
---|---|
Trade names | Mekinist, Spexotras |
Other names | GSK1120212 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a613040 |
License data |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.158.135 ![]() |
Chemical and physical data | |
Formula | C26H23FIN5O4 |
Molar mass | 615.404 g·mol−1 |
3D model (JSmol) | |
| |
|
The most common side effects include rash, diarrhea, tiredness, peripheral edema (swelling, especially of ankles and feet), nausea and acneiform dermatitis (acne-like inflammation of the skin).[5] When taken in combination with dabrafenib the most common side effects include fever, tiredness, nausea, chills, headache, diarrhea, vomiting, joint pain and rash.[5]
In May 2013, trametinib was approved as a single-agent by the US Food and Drug Administration for the treatment of people with V600E mutated metastatic melanoma.[9][10] It was approved for medical use in the European Union in June 2014.[5]