Loading AI tools
Chemical compound From Wikipedia, the free encyclopedia
Tocofersolan (INN; also known as tocophersolan, tocopherol polyethylene glycol succinate, or TPGS) is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.
Names | |
---|---|
IUPAC name
α-Hydro-ω-{[4-oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-yl}oxy)butanoyl]oxy}poly(oxyethylene) | |
Other names
Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E | |
Identifiers | |
3D model (JSmol) |
|
ChEMBL | |
ChemSpider | |
DrugBank | |
ECHA InfoCard | 100.123.651 |
EC Number |
|
PubChem CID |
|
UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
Properties | |
(C2H4O)nC33H54O5 | |
Molar mass | Variable |
Pharmacology | |
A11HA08 (WHO) | |
License data | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Clinical data | |
---|---|
Trade names | Vedrop |
Other names | Tocophersolan (USAN US) |
AHFS/Drugs.com | UK Drug Information |
Legal status | |
Legal status | |
Identifiers | |
DrugBank | |
KEGG | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.123.651 |
Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients with congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[4]
Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[5]
Seamless Wikipedia browsing. On steroids.
Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.
Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.