1806 - April 28: The Lewis and Clark Expedition passes through the Tri-Cities area on their return journey.[3]
1811 - Members of the Astor Expedition likely passed through the Tri-Cities traveling on the Snake and Columbia Rivers.[4]
1824 - June 29: As part of the Oregon boundary dispute, the British propose a boundary between the United States and British North America using the Columbia River in a manner that would have split the region, placing what is now Kennewick and Richland in British territory with the Pasco side of the river being American territory. This proposal was rejected by the United States.[5]
1847 - The St. Rose of Chemna Catholic mission was established approximately 3 miles from the confluence of the Columbia and Yakima Rivers on the south bank, at the approximate location of the current I-182 bridge in South Richland. The mission was reported abandoned as late as 1859.[6][7][8]
1922 - The Pasco-Kennewick Bridge, informally known as the Green Bridge, opens allowing automobile traffic to cross the Columbia without a ferry for the first time in the area.[25]
Naval Air Station Pasco is established, becoming one of the three busiest naval aviation training facilities of World War II.[30][31]
June 1: Grand Coulee Dam, part of the Columbia Basin Project, is completed allowing water from the Columbia River to be used for irrigation in and north of Pasco.
February 9: Selection of the Hanford Site is approved as part of the Manhattan Project, encompassing Richland and a large portion of Benton County to the north of town.
1944 - September: The B Reactor on the Hanford Site is completed, becoming the first large-scale nuclear reactor in the world.[33]
1945
May 7: Plutonium from the Hanford Site is used at the Trinity Site near Socorro, New Mexico in the world's first test of a nuclear bomb.
1947 - November 13: The Pasco Herald (formerly the Pasco Express) moves to Kennewick, rebrands as the Tri-City Herald, and becomes a daily newspaper.[35]
1958 - November: Port of Benton is created with a port district covering all of the parts of Benton County that weren't included in the Port of Kennewick's district.[32]
1961
Ice Harbor Dam opens on the Snake River upstream of Pasco.
1978 - September 8: The Cable Bridge, officially known as the Ed Hendler Bridge, opens replacing the Pasco-Kennewick Bridge (Green Bridge) built in 1922.
Bagwell, Steve; Stapilus, Randy (2013). New Editions: The Northwest's newspapers as they were, are, and will be. Carlton, Oregon: Ridenbaugh Press. pp.223–224. ISBN978-0-945648-10-9. OCLC861618089.
"2017 Nobel Prize in Physics" (Press release). Royal Swedish Academy of Sciences. 3 October 2017. The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics 2017 with one half to Rainer Weiss, LIGO/VIRGO Collaboration and the other half jointly to Barry C. Barish, LIGO/VIRGO Collaboration, and Kip S. Thorne, LIGO/VIRGO Collaboration, 'for decisive contributions to the LIGO detector and the observation of gravitational waves'