Thonzylamine

Thonzylamine (or neohetramine)^[1] is an antihistamine and anticholinergic used as an antipruritic.

Thonzylamine

Clinical data
Other names	Neohetramine
AHFS/Drugs.com	International Drug Names
ATC code	D04AA01 (WHO) R01AC06 (WHO) R06AC06 (WHO)
Identifiers
IUPAC name N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyrimidin-2-ylethane-1,2-diamine
CAS Number	91-85-0 N 63-56-9
PubChem CID	5457
ChemSpider	5258 Y
UNII	R79646H5Z8
KEGG	D08587 Y
ChEMBL	ChEMBL1623738 N
CompTox Dashboard (EPA)	DTXSID8043864
ECHA InfoCard	100.001.913
Chemical and physical data
Formula	C16H22N4O
Molar mass	286.379 g·mol−1
3D model (JSmol)	Interactive image
SMILES n1cccnc1N(CCN(C)C)Cc2ccc(OC)cc2
InChI InChI=1S/C16H22N4O/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14/h4-10H,11-13H2,1-3H3 Y Key:GULNIHOSWFYMRN-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Synthesis

Thonzylamine synthesis: H. L. Friedman and A, V. Tolstouhov, U.S. patent 2,465,865 (1949).

See also

• Zolamine

References

1. Arminio JJ, Sweet CC (December 1949). "The prophylaxis and treatment of the common cold with neohetramine (thonzylamine hydrochloride)". Industrial Medicine & Surgery. 18 (12): 509–11. PMID 15393969.