THOC2

THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene.^[5][6]

THOC2
Identifiers
Aliases	THOC2, CXorf3, THO2, dJ506G2.1, hTREX120, MRX12, MRX35, THO complex 2
External IDs	OMIM: 300395; MGI: 2442413; HomoloGene: 69669; GeneCards: THOC2; OMA:THOC2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq25 Start 123,600,561 bp[1] End 123,733,056 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A4 Start 40,883,868 bp[2] End 41,009,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon sural nerve ventricular zone epithelium of colon right lung visceral pleura left ovary gastric mucosa body of pancreas Top expressed in Rostral migratory stream sciatic nerve retinal pigment epithelium primitive streak ciliary body tail of embryo medullary collecting duct umbilical cord vestibular membrane of cochlear duct median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding mRNA binding Cellular component THO complex nuclear speck THO complex part of transcription export complex transcription export complex nucleus nucleoplasm Biological process poly(A)+ mRNA export from nucleus mRNA processing mRNA transport neuron development viral mRNA export from host cell nucleus RNA splicing generation of neurons RNA export from nucleus mRNA export from nucleus mRNA 3'-end processing cell morphogenesis blastocyst development regulation of gene expression regulation of mRNA export from nucleus negative regulation of neuron projection development stem cell division Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57187 331401 Ensembl ENSG00000125676 ENSMUSG00000037475 UniProt Q8NI27 B1AZI6 RefSeq (mRNA) NM_001081550 NM_020449 NM_001033422 RefSeq (protein) NP_001075019 NP_001028594 Location (UCSC) Chr X: 123.6 – 123.73 Mb Chr X: 40.88 – 41.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

THO2 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125676 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037475 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
6. "Entrez Gene: THOC2 THO complex 2".

Further reading

• Coffey AJ, Brooksbank RA, Brandau O, et al. (1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene". Nat. Genet. 20 (2): 129–35. doi:10.1038/2424. PMID 9771704. S2CID 9347438.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.