Suprofen

Suprofen
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Oral, eye drops
ATC code	M01AE07 (WHO) ;
Legal status
Legal status	Discontinued;
Pharmacokinetic data
Protein binding	20%
Identifiers
	IUPAC name (RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid;
CAS Number	40828-46-4 ;
PubChem CID	5359;
IUPHAR/BPS	7298;
DrugBank	DB00870 ;
ChemSpider	5166 ;
UNII	988GU2F9PE;
KEGG	D00452 ;
ChEBI	CHEBI:9362 ;
ChEMBL	ChEMBL956 ;
CompTox Dashboard (EPA)	DTXSID5045469 ;
ECHA InfoCard	100.050.071
Chemical and physical data
Formula	C14H12O3S
Molar mass	260.31 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2;
	InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) ; Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N ;
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Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica^[1] that was marketed as 1% eye drops under the trade name Profenal.

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Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects.^[2] It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery.^[3] This application has been discontinued as well, at least in the US.^[4]

[1]
DE 2353357, Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", issued 1974
[2]
Nies AS (1988). "Renal Effects of Nonsteroidal Anti-Inflammatory Drugs". Basis for Variability of Response to Anti-Rheumatic Drugs. Vol. 24. pp. 95–106. doi:10.1007/978-3-0348-9160-8_9 (inactive 1 November 2024). ISBN 978-3-0348-9931-4. PMID 3142236. {{cite book}}: |journal= ignored (help)CS1 maint: DOI inactive as of November 2024 (link)
[3]
"Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. Archived from the original on 1 January 2009.
[4]
"Suprofen ophthalmic". Drugs.com. Archived from the original on 2021-09-09. Retrieved 2018-01-23.

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[1] [1]
DE 2353357, Janssen PA, Van Daele GH, Boey JM, "Antiphlogistic aroyl-substituted phenylacetic acid derivatives", issued 1974

[2] [2]
Nies AS (1988). "Renal Effects of Nonsteroidal Anti-Inflammatory Drugs". Basis for Variability of Response to Anti-Rheumatic Drugs. Vol. 24. pp. 95–106. doi:10.1007/978-3-0348-9160-8_9 (inactive 1 November 2024). ISBN 978-3-0348-9931-4. PMID 3142236. {{cite book}}: |journal= ignored (help)CS1 maint: DOI inactive as of November 2024 (link)

[3] [3]
"Pharmacy Compounding". Guidance for FDA Staff and Industry Compliance Policy Guides Manual. U.S. Food and Drug Administration. Archived from the original on 1 January 2009.

[4] [4]
"Suprofen ophthalmic". Drugs.com. Archived from the original on 2021-09-09. Retrieved 2018-01-23.

[1]

[2]

[3]

[4]

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Suprofen

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Uses

References

Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Oral, eye drops
ATC code	M01AE07 (WHO)
Legal status
Legal status	Discontinued
Pharmacokinetic data
Protein binding	20%
Identifiers
IUPAC name (RS)-2-[4-(2-thienylcarbonyl)phenyl]propanoic acid
CAS Number	40828-46-4^Y
PubChem CID	5359
IUPHAR/BPS	7298
DrugBank	DB00870^Y
ChemSpider	5166^N
UNII	988GU2F9PE
KEGG	D00452^Y
ChEBI	CHEBI:9362^N
ChEMBL	ChEMBL956^N
CompTox Dashboard (EPA)	DTXSID5045469
ECHA InfoCard	100.050.071
Chemical and physical data
Formula	C₁₄H₁₂O₃S
Molar mass	260.31 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(c1ccc(cc1)C(C(=O)O)C)c2sccc2
InChI InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)^N Key:MDKGKXOCJGEUJW-UHFFFAOYSA-N^N
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