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Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions.[1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator,[2][3] and previously served as chair of the Department of Genome Sciences.[4]
Stan Fields | |
|---|---|
| Born | Stanley Fields |
| Alma mater | University of Cambridge |
| Known for | Two-hybrid screening |
| Scientific career | |
| Institutions | |
| Thesis | Sequence analysis of influenza virus RNA (1981) |
| Website | |
Fields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology with Greg Winter and George Brownlee.[5][6]
Fields developed the yeast two-hybrid system in 1989,[1] which has been widely used by Fields[7][8][9][10] and others to identify protein-protein interactions in various organisms and biological contexts.
Along with Matt Kaeberlein and Brian Kennedy, in later work Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins.[11] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase.[12]
- 2003 Jacob Heskel Gabbay Award in Biotechnology and Medicine (jointly with Roger Brent) [13]
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