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Chemical compound From Wikipedia, the free encyclopedia
Solasonine is a glycoalkaloid that is found in Solanum plants of the family Solanaceae.[1] Solasonine is a poisonous chemical compound when used at high levels. It is a glycoside of solasodine. Glycoalkaloids such as Solasonine have various applications including pharmacology, cancer treatments and even a role as a pesticide.
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3D model (JSmol) |
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ChEBI | |
ChEMBL | |
ECHA InfoCard | 100.038.917 |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C 45H 73NO 16 | |
Molar mass | 884.07 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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High levels of glycoalkaloids are toxic to humans due to their ability to disrupt cell-membrane function.[2] There is a loss of membrane integrity which puts the cell at risk for apoptosis (cell death) due to the ability of any chemical coming into contact with the cell.
Solasonine was one component of the unsuccessful experimental cancer drug candidate Coramsine.
Although, solasonine has anti-infection properties it has many adverse side effects as a steroidal glycoalkaloid.[3] These side effects include low blood pressure, a decrease in respiratory activity, rapid heart beat etc.[3] These side effects are the direct result of the cytotoxic properties of solasonine (at high levels) that lead to disrupted cell membranes.
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