Sodium zirconium cyclosilicate
Medication used to treat high blood potassium / From Wikipedia, the free encyclopedia
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Sodium zirconium cyclosilicate, sold under the brand name Lokelma, is a medication used to treat high blood potassium.[4] Onset of effects occurs in one to six hours.[4] It is taken by mouth.[4]
Quick Facts Clinical data, Trade names ...
Clinical data | |
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Trade names | Lokelma |
Other names | ZS-9 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a618035 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | Not absorbed |
Excretion | Feces |
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Chemical and physical data | |
Formula | (2Na·H2O·3H4SiO4·H4ZrO6)n |
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Common side effects include swelling and low blood potassium.[4] Use is likely safe in pregnancy and breastfeeding.[4] It works by binding potassium ions in the gastrointestinal tract which is then lost in the stool.[4][5]
Sodium zirconium cyclosilicate was approved for medical use in the European Union and in the United States in 2018.[4][3][6] It was developed by AstraZeneca.[4]