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Sodium thiosulfate (medical use)
From Wikipedia, the free encyclopedia
Sodium thiosulfate, also spelled sodium thiosulphate, is used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin.[3][4][5] For cyanide poisoning, it is often used after the medication sodium nitrite and is typically only recommended for severe cases.[4][6] It is either given by injection into a vein or applied to the skin.[4]
![]() Sodium thiosulfate, structural formula | |
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Trade names | Pedmark, Pedmarqsi |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | Intravenous |
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Formula | Na2O3S2 |
Molar mass | 158.10 g·mol−1 |
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Side effects may include vomiting, joint pain, mood changes, psychosis, and ringing in the ears.[5] Safety, however, has not been well studied.[7] It is unclear if use during pregnancy is safe for the baby.[5] Its use at the same time in the same intravenous line as hydroxocobalamin is not recommended.[6] In cyanide poisoning, sodium nitrite creates methemoglobinemia, which removes cyanide from the mitochondria.[6] Sodium thiosulfate then binds with cyanide, creating the nontoxic thiocyanate.[6]
Sodium thiosulfate came into medical use for cyanide poisoning in the 1930s.[8] It is on the World Health Organization's List of Essential Medicines.[9]