Small nucleolar RNA SNORD14

In molecular biology, U14 small nucleolar RNA (U14 snoRNA) is a non-coding RNA required for early cleavages of eukaryotic precursor rRNAs. In yeasts, this molecule possesses a stem-loop region (known as the Y-domain) which is essential for function. A similar structure, but with a different consensus sequence, is found in plants, but is absent in vertebrates.^[1] In human there are two closely related copies called SNORD14A and SNORD14B that are expressed from the intron of their host gene ribosomal protein Rps13.

Small nucleolar RNA SNORD14
Predicted secondary structure and sequence conservation of SNORD14
Identifiers
Symbol	SNORD14
Alt. Symbols	U14
Rfam	RF00016
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000593
PDB structures	PDBe

References

1. Samarsky DA, Schneider GS, Fournier MJ (June 1996). "An essential domain in Saccharomyces cerevisiae U14 snoRNA is absent in vertebrates, but conserved in other yeasts". Nucleic Acids Research. 24 (11): 2059–66. doi:10.1093/nar/24.11.2059. PMC 145897. PMID 8668536.

External links

• Page for Small nucleolar RNA SNORD14 at Rfam
• Entry for U14A at snoRNABase
• Entry for SNORD14A in HGNC database^{[permanent dead link]}
• Entry for U14B at snoRNABase
• Entry for SNORD14B in HGNC database^{[permanent dead link]}