Skraup reaction
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The Skraup synthesis is a chemical reaction used to synthesize quinolines. It is named after the Czech chemist Zdenko Hans Skraup (1850-1910). In the archetypal Skraup reaction, aniline is heated with sulfuric acid, glycerol, and an oxidizing agent such as nitrobenzene to yield quinoline.[1][2][3][4]
![The Skraup reaction](http://upload.wikimedia.org/wikipedia/commons/thumb/6/66/Skraup_Reaktion_overview_V1-Seite001.svg/640px-Skraup_Reaktion_overview_V1-Seite001.svg.png)
Quick Facts Identifiers ...
Skraup reaction | |
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Named after | Zdenko Hans Skraup |
Reaction type | Ring forming reaction |
Identifiers | |
RSC ontology ID | RXNO:0000062 |
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In this example, nitrobenzene serves as both the solvent and the oxidizing agent. The reaction, which otherwise has a reputation for being violent, is typically conducted in the presence of ferrous sulfate.[5] Arsenic acid may be used instead of nitrobenzene and the former is better since the reaction is less violent.[6]