Secretin receptor family
Protein family / From Wikipedia, the free encyclopedia
Dear Wikiwand AI, let's keep it short by simply answering these key questions:
Can you list the top facts and stats about Secretin receptor family?
Summarize this article for a 10 year old
Secretin receptor family (class B GPCR subfamily[1]) consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family is different from adhesion G protein-coupled receptors.[2]
Secretin family of 7 transmembrane receptors | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | 7tm_2 | ||||||||
Pfam | PF00002 | ||||||||
InterPro | IPR000832 | ||||||||
PROSITE | PDOC00559 | ||||||||
TCDB | 9.A.14 | ||||||||
OPM superfamily | 6 | ||||||||
OPM protein | 4k5y | ||||||||
CDD | cd13952 | ||||||||
|
The secretin-receptor family of GPCRs include vasoactive intestinal peptide receptors and receptors for secretin, calcitonin and parathyroid hormone/parathyroid hormone-related peptides. These receptors activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. The receptors in this family have 7 transmembrane helices,[3][4] like rhodopsin-like GPCRs. However, there is no significant sequence identity between these two GPCR families and the secretin-receptor family has its own characteristic 7TM signature.[5]
The secretin-receptor family GPCRs exist in many animal species. Data mining with the Pfam signature has identified members in fungi, although due to their presumed non-hormonal function they are more commonly referred to as Adhesion G protein-coupled receptors, making the Adhesion subfamily the more basal group.[6] Three distinct sub-families (B1-B3) are recognized.