SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.[5][6][7]
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SMARCB1 |
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Identifiers |
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Aliases | SMARCB1, BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS, CSS3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1, INI-1 |
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External IDs | OMIM: 601607; MGI: 1328366; HomoloGene: 2310; GeneCards: SMARCB1; OMA:SMARCB1 - orthologs |
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Wikidata |
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The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.[8]
SMARCB1 has been shown to interact with:
- ARID1A,[9][10]
- BAZ1B,[11]
- BRCA1,[12]
- CREB-binding protein,[13]
- Cyclin-dependent kinase 8,[13]
- Myc,[6]
- P53,[14]
- POLR2A,[9][13][15]
- PPP1CA,[16]
- PPP1CB,[16]
- PPP1CC,[16]
- PPP1R15A,[16][17]
- SMARCA2,[9][15]
- SMARCA4,[9][15][18][19][20]
- SMARCC1,[9][15]
- SMARCE1,[9][18]
- SS18,[10] and
- XPO1.[21]
Kalpana GV, Marmon S, Wang W, Crabtree GR, Goff SP (January 1995). "Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5". Science. 266 (5193): 2002–6. doi:10.1126/science.7801128. PMID 7801128. Cheng SW, Davies KP, Yung E, Beltran RJ, Yu J, Kalpana GV (May 1999). "c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function". Nat Genet. 22 (1): 102–5. doi:10.1038/8811. PMID 10319872. S2CID 12945791. Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581. Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (February 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. hdl:2066/170683. PMID 11734557. Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/s0092-8674(03)00436-7. PMID 12837248. Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM (November 2001). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. 10 (23): 2651–60. doi:10.1093/hmg/10.23.2651. PMID 11726552.
- Miller MD, Bushman FD (1995). "HIV integration. Ini1 for integration?". Curr. Biol. 5 (4): 368–70. doi:10.1016/S0960-9822(95)00074-1. PMID 7627549. S2CID 17647431.
- Van Maele B, Debyser Z (2005). "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins". AIDS Reviews. 7 (1): 26–43. PMID 15875659.
- Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z (2006). "Cellular co-factors of HIV-1 integration". Trends Biochem. Sci. 31 (2): 98–105. doi:10.1016/j.tibs.2005.12.002. PMID 16403635.
- Judkins AR (2007). "Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology". Advances in Anatomic Pathology. 14 (5): 335–9. doi:10.1097/PAP.0b013e3180ca8b08. PMID 17717433. S2CID 27654280.
- Muchardt C, Sardet C, Bourachot B, Onufryk C, Yaniv M (1995). "A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm". Nucleic Acids Res. 23 (7): 1127–32. doi:10.1093/nar/23.7.1127. PMC 306820. PMID 7739891.
- Wu DY, Kalpana GV, Goff SP, Schubach WH (1996). "Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1". J. Virol. 70 (9): 6020–8. doi:10.1128/JVI.70.9.6020-6028.1996. PMC 190622. PMID 8709224.
- Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. doi:10.1002/j.1460-2075.1996.tb00921.x. PMC 452280. PMID 8895581.
- Morozov A, Yung E, Kalpana GV (1998). "Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region". Proc. Natl. Acad. Sci. U.S.A. 95 (3): 1120–5. Bibcode:1998PNAS...95.1120M. doi:10.1073/pnas.95.3.1120. PMC 18693. PMID 9448295.
- Versteege I, Sévenet N, Lange J, Rousseau-Merck MF, Ambros P, Handgretinger R, Aurias A, Delattre O (1998). "Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer". Nature. 394 (6689): 203–6. Bibcode:1998Natur.394..203V. doi:10.1038/28212. PMID 9671307. S2CID 6019090.
- Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi:10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
- Biegel JA, Zhou JY, Rorke LB, Stenstrom C, Wainwright LM, Fogelgren B (1999). "Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors". Cancer Res. 59 (1): 74–9. PMID 9892189.
- Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell. 3 (2): 247–53. doi:10.1016/S1097-2765(00)80315-9. PMID 10078207.
- Bruder CE, Dumanski JP, Kedra D (1999). "The mouse ortholog of the human SMARCB1 gene encodes two splice forms". Biochem. Biophys. Res. Commun. 257 (3): 886–90. doi:10.1006/bbrc.1999.0563. PMID 10208879.
- Adler HT, Chinery R, Wu DY, Kussick SJ, Payne JM, Fornace AJ, Tkachuk DC (2000). "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins". Mol. Cell. Biol. 19 (10): 7050–60. doi:10.1128/mcb.19.10.7050. PMC 84700. PMID 10490642.
- Sévenet N, Sheridan E, Amram D, Schneider P, Handgretinger R, Delattre O (1999). "Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers". Am. J. Hum. Genet. 65 (5): 1342–8. doi:10.1086/302639. PMC 1288286. PMID 10521299.
- Kowenz-Leutz E, Leutz A (2000). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes". Mol. Cell. 4 (5): 735–43. doi:10.1016/S1097-2765(00)80384-6. PMID 10619021.