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Riociguat
Chemical compound / From Wikipedia, the free encyclopedia
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Riociguat, sold under the brand name Adempas, is a medication by Bayer that is a stimulator of soluble guanylate cyclase (sGC). It is used to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of the class of sGC stimulators.[4] The drug has a half-life of 12 hours and will decrease dyspnea associated with pulmonary arterial hypertension.
Quick Facts Clinical data, Trade names ...
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Clinical data | |
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Trade names | Adempas |
Other names | BAY 63-2521 |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth |
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Bioavailability | 94% |
Protein binding | 95% |
Metabolism | CYP1A1, CYP3A4, CYP2C8, CYP2J2 |
Metabolites | N-desmethylriociguat (active), glucuronide (inactive) |
Elimination half-life | 12 h (patients); 7 h (healthy people)[3] |
Excretion | 33–45% via kidney, 48–59% via bile duct |
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ECHA InfoCard | 100.169.606 ![]() |
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Formula | C20H19FN8O2 |
Molar mass | 422.424 g·mol−1 |
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It is available as a generic medication.[5]