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Chemical compound From Wikipedia, the free encyclopedia
Rigosertib (ON-01910 sodium salt, with Estybon as trade name) is a synthetic benzyl styryl sulfone in development by Onconova Therapeutics.[3] Rigosertib is in phase III clinical trials for the treatment of chronic myelomonocytic leukemia.[4]
Names | |
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IUPAC name
(2-Methoxy-5-{[(E)-2-(2,4,6-trimethoxyphenyl)ethene-1-sulfonyl]methyl}phenyl)glycine | |
Systematic IUPAC name
(2-Methoxy-5-{[(E)-2-(2,4,6-trimethoxyphenyl)ethene-1-sulfonyl]methyl}anilino)acetate | |
Other names
ON-01910 | |
Identifiers | |
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ChEBI | |
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CompTox Dashboard (EPA) |
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Properties | |
C21H25NO8S | |
Molar mass | 451.49 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Its geometrical isomer (Z)-ON 01910·Na has less cytotoxicity on cancer cells.
Rigosertib is a microtubule-destabilizing agent.[5]
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